Alice Melao,  —

AC-203, also known as CCP-020, is advancing to a Phase 2 clinical trial as a potential treatment for patients with inherited epidermolysis bullosa (EB), TWi Biotechnology announced. The proof-of-concept trial, which was approved by the Taiwan Food and Drug Administration, is designed to provide data on the…

A rare case of hair loss associated with PLEC gene mutation and epidermolysis bullosa simplex with muscular dystrophy was reported for the second time in a patient from the Azores. The case report was published in the journal BMC Dermatology. Epidermolysis bullosa (EB) is caused by…

Data from a Phase 2 trial validated a new five-point Investigator’s Global Assessment (IGA) scale for the clinical evaluation of patients with epidermolysis bullosa simplex (EBS), the scale’s developer, Castle Creek Pharmaceuticals (CCP), announced. In September 2017, CCP presented the five-point IGA scale that defines skin symptoms as clear, almost…

Skin colonization by bacteria resistant to Bactroban (mupirocin) is frequent among patients with epidermolysis bullosa (EB), and may be due to home skin care practices, according to researchers at Columbia University. The finding was reported in the study “Wound culture isolated antibiograms and caregiver-reported skin…

The systemic administration of collagen VII protein can reduce bacteria in the skin of mice with epidermolysis bullosa (EB), according to a report published in the journal Proceedings of the National Academy of Sciences. The study, “Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa,” showed that…

Diacerein, which is a commercially available medicine used to treat osteoarthritis, also may hold therapeutic potential to treat blistering in patients with epidermolysis bullosa simplex type Dowling-Meara (EBS-DM). Initially discovered by a team of researchers at the EB House Austria, University Clinic for Dermatology at the Paracelsus Medical…

InMed Pharmaceuticals has filed a provisional patent application covering its proprietary cannabinoid manufacturing system based on E. coli bacteria. This is the first of a series of patent applications the company plans to pursue covering different aspects of its biosynthesis system. InMed is currently exploring the therapeutic potential of two cannabinoid-based…

The U.S. Food and Drug Administration (FDA) recently recommended Abeona Therapeutics accelerate the clinical development program of its gene therapy candidate EB-101 for the treatment of patients with recessive dystrophic epidermolysis bullosa (RDEB), also known as “butterfly skin” syndrome. With the recommendation, which came in a recent Type-C meeting with the…

The U.S. Food and Drug Administration has granted a Rare Pediatric Disease Designation to EB-101,  Abeona Therapeutics’ treatment for the inherited skin disease epidermolysis bullosa, or EB. Importantly, the designation also covers a severe form of the blistering and open-wound disorder known as recessive dystrophic epidermolysis bullosa, or RDEB. The FDA…