Mechanism Underlying Fibrosis in RDEB Could Be New Therapeutic Target
In the absence of collagen 7, the protein missing in recessive dystrophic epidermolysis bullosa (RDEB) patients, the protein thrombospondin-1 (TSP1) plays a key role in the development of fibrosis, or scarred tissue. This newly discovered mechanism suggests TSP1 as a potential therapeutic target for RDEB patients. The study, “Thrombospondin-1 is a major…